Journal of Manipulative and Physiological Therapeutics
Volume 26, Issue 7 , Pages 426-436 , September 2003

Onset and recovery of hyperalgesia and hyperexcitability of sensory neurons following intervertebral foramen volume reduction and restoration

  • Xue-Jun Song, PhD, MD

      Affiliations

    • Senior Scientist, Associate Professor, and Associate Director of Basic Science Research, Department of Neurobiology, Parker Research Institute, Dallas, Tex, USA
    • Corresponding Author InformationSubmit requests for reprints to: Dr. XJ Song, Department of Neurobiology, Parker Research Institute, 2500 Walnut Hill Lane, Dallas, TX 75229, USA
    • ,
  • Dong-Sheng Xu, MD

      Affiliations

    • Research Associate, Department of Neurobiology, Parker Research Institute, Dallas, Tex, USA
    • ,
  • Carlos Vizcarra, MD

      Affiliations

    • Research Associate, Department of Neurobiology, Parker Research Institute, Dallas, Tex, USA
    • ,
  • Ronald L Rupert, DC

      Affiliations

    • Director of Research, Department of Neurobiology, Parker Research Institute, Dallas, Tex, USA

Received 2 May 2002 ,Revised 11 June 2002

References 

  1. Devor M. The pathophysiology of damaged peripheral nerves. In: Wall PD, Melzack R, editors. Textbook of pain. 3rd ed. London: Churchill Livingstone; 1994. p. 79-100
  2. Leach RA. Vertebral subluxation complex hypothesis. In:  In: Leach RA editors. The chiropractic theories, principles and clinical applications. 3rd ed. Baltimore: Williams & Wilkins; 1994;p. 201–230
  3. Boone WR, Dobson GJ. A proposed vertebral subluxation model reflecting traditional concepts and recent advances in health and science. J Vertebral Subluxation Res. 1996;1:1–12
  4. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 1988;33:87–107
  5. Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 1992;50:355–363
  6. Seltzer Z, Dubner R, Shir Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain. 1990;43:205–218
  7. Wall PD, Devor M. Sensory afferent impulses originate from dorsal root ganglion as well as from the periphery in normal and injured rats. Pain. 1983;17:321–339
  8. Kajander KC, Bennett GL. Onset of a painful neuropathy in rat (a partial and deferential deafferentiation and spontaneous discharge in Aβ and Aδ primary afferent neurons). J Neurophysiol. 1992;68:734–744
  9. McLachlan EM, Janig W, Michalis M. Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia. Nature. 1993;363:543–546
  10. Song XJ, Hu SJ, Zhang J, Greenquist KW, LaMotte RH. Cutaneous hyperalgesia during chronic compression of dorsal root ganglion. Abstr Soc Neurosci. 1997;23:497–512
  11. Song XJ, Hu SJ, Greenquist KW, Zhang J, LaMotte RH. Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia. J Neurophysiol. 1999;82:3347–3358
  12. Hu SJ, Xing J. An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat. Pain. 1998;77:15–23
  13. Hu SJ, Yang HJ, Jian Z, Long KP, Duan YB, Wan YH, et al.  Adrenergic sensitivity of neurons with non-periodic firing activity in rat injured dorsal root ganglion. Neuroscience. 2000;101:689–698
  14. Zhang JM, Song XJ, LaMotte RH. Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion. J Neurophysiol. 1999;82:3371–3378
  15. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 1988;32:77–88
  16. LaMotte RH, Song XJ, Greenquist KW, Zhang J. Withdrawal threshold to mechanical indentation and to controlled-temperature heating of the rat hind paw. Abstr Soc Neurosci. 1998;24:629
  17. Anderson P, Storm J, Wheal HV. The thresholds of action potentials evoked by synapses on the dendrites of pyramidal cells in the rat hippocampus in vitro. J Physiol (Lond). 1987;383:509–526
  18. Abdulla FA, Smith PA. Axotomy- and autotomy-induced changes in the excitability of dorsal root ganglion neurons. J Neurophysiol. 2001;85:630–643
  19. Abdulla FA, Smith PA. Axotomy- and autotomy-induced changes in Ca2+ and K+ currents of rat dorsal root ganglion neurons. J Neurophysiol. 2001;85:644–658
  20. Rizzo MA, Kocsis JD, Waxman SG. Selective loss of slow and enhancement of fast Na+ currents in cutaneous afferent dorsal root ganglion neurones following axotomy. Neurobiol Dis. 1995;2:87–96
  21. Rydevik Z, Myers RR, Powell HC. Pressure increase in the dorsal root ganglion following mechanical compression (closed compartment syndrome in nerve roots). Spine. 1989;14:574–576
  22. Olmarker K, Myers RR. Pathogenesis of sciatic pain (role of herniated nucleus pulposus and deformation of spinal nerve root and dorsal root ganglion). Pain. 1988;78:99–105
  23. Weinstein J. Mechanisms of spinal pain (the dorsal root ganglion and its role as a mediator of low-back pain). Spine. 1986;111:999–1001
  24. Wagner R, Myers RR. Endoneurial injection of TNF-alpha produces neuropathic pain behaviors. Neuroreport. 1996;7:103–111
  25. Waxman SG, Kocsis JD, Black JA. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is re-expressed following axotomy. J Neurophysiol. 1994;72:466–470
  26. Kandel ER. Genes, synapses, and long-term memory. J Cell Physiol. 1997;173:124–125
  27. Walters ET, Ambron RT. Long-term alterations induced by injury and by 5-HT in aplysia sensory neurons (convergent pathways and common signals?). Trends Neurosci. 1995;18:137–142
  28. Lewin MR, Walters ET. Cyclic GMP pathway is critical for inducing long-term sensitization of nociceptive sensory neurons. Nat Neurosci. 1999;2:18–23
  29. Ji RR, Woolf CJ. Neuronal plasticity and signal transduction in nociceptive neurons (implications for the initiation and maintenance of pathological pain). Neurobiol Dis. 2001;8:1–10
  30. Neumann S, Doubell TP, Leslie T, Woolf CJ. Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons. Nature. 1996;384:360–364
  31. Lu X, Richardson PM. Responses of macrophages in rat dorsal root ganglion following peripheral nerve injury. J Neurocytol. 1993;22:334–341
  32. Cui JG, Holmin S, Mathiesen T, Meyerson BA, Linderoth B. Possible role of inflammatory mediators in tactile hypersensitivity in rat models of mononeuropathy. Pain. 2000;88:239–248

☆ This study was supported by the basic science research grant from Parker Research Institute (PCCRF-BSR990601).

PII: S0161-4754(03)00091-5

doi: 10.1016/S0161-4754(03)00091-5

Journal of Manipulative and Physiological Therapeutics
Volume 26, Issue 7 , Pages 426-436 , September 2003

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