Journal of Manipulative and Physiological Therapeutics
Volume 33, Issue 1 , Pages 76-79 , January 2010

Effects of a Manual Medicine Treatment Procedures on Nitric Oxide Release in 23 Healthy Adults

  • James E. Kiernan, MS, DC

      Affiliations

    • Corresponding Author InformationSubmit requests for reprints to: James E. Kiernan, MS, DC, Kiernan Wellness Center, 115-06 Beach Channel Drive, Rockaway Park, NY 11694

Received 15 December 2008 ,Revised 1 September 2009

References 

  1. Schleip R. Fascial plasticity—a new neurobiological explanation. J Bodyw Mov Ther. 2003;7:104–116
  2. Bialosky JE, Bishop MD, Robinson ME, Barabas JA, George SZ. The influence of expectation on spinal manipulation induced hypoalgesia: an experimental study in normal subjects. BMC Musculoskelet Disord. 2008;9:19
  3. Boal RW, Gillette RG. Central neuronal plasticity, low back pain and spinal manipulative therapy. J Manipulative Physiol Ther. 2004;27:314–326
  4. Esch T, Stefano GB. Love promotes health. Neuroendocrinol Lett. 2005;26:
  5. Hoffman JW, Benson H, Arns PA, Stainbrook GL, Landsberg GL, Young JB, et al. Reduced sympathetic nervous system responsitivity associated with the relaxation response. Science. 1982;215:190–192
  6. Stefano GB, Fricchione GL, Slingby BT, Benson H. The placebo effect and relaxation response: neural processes and their coupling to constitutive nitric oxide. Brain Res. 2001;35:1–19
  7. Roy RA, Boucher JP, Comtois AS. Heart rate variability modulation after manipulation in pain-free patients vs patients in pain. J Manipulative Physiol Ther. 2009;32:277–286
  8. Budgell B, Polus B. The effects of thoracic manipulation on heart rate variability: a controlled crossover trial. J Manipulative Physiol Ther. 2006;29:603–661
  9. Furchgott R, Ignarro L, Murad F. Nobelförsamlingen karolinska institutet. The nobel assembly at karolinska institutet for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular system. Press Release. 1998;
  10. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide physiology, pathophysiology, and pharmacology. Pharmacol Rev. 1991;43:109–142
  11. Wink DA, Miranda KM, Espey MG, Pluta RM, Hewett SJ, Cotton C, et al. Mechanisms of the antioxidant effects of nitric oxide. Antioxid Redox Signal. 2001;3:203–213
  12. Svegliati-Barone G, Saccomanno S, van Goor H, Janson P, Benedetti A, Moshage H. Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells. Liver. 2001;21:1–12
  13. Kim DH, Moon YS, Kim HS, Jung JS, Park HM, Suh HW, et al. Effect of Zen Meditation on serum nitric oxide activity and lipid peroxidation. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29:327–331
  14. Cheng J, Zhang C, Han JS, Stefano G, Kream RM. TENS stimulates constitutive nitric oxide release via opiate signaling in invertebrate neural tissues. Med Sci Monit. 2007;13:BR163–7
  15. Jungersten L, Ambring A, Wall B, Wennmalm A. Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans. J Appl Physiol. 1997;82:760–764
  16. Ivivi Technologies Inc. PEMF, herbal remedies claim Nitric oxide production as the driving engine behind their success MONTVALE, N.J., June 30, 2008 (PRIME NEWSWIRE).
  17. Eagan TS, Mettzer KR, Standley PR. Importance of strain direction in regulating human fibroblast proliferation and cytokine secretion: a useful in vitro model for soft tissue injury and manual medicine treatment. J Manipulative Physiol Ther. 2007;584–592
  18. Mantione KJ, Esch T, Stefano GB. Detection of nitric oxide in exhaled human breath: exercise and resting determinations. Med Sci Monit. 2007;13:mt1–5
  19. Hamid Q, Springall DR, Riveros-Moreno V, Chanez P, Howarth P, Redington A, et al. Induction of nitric oxide synthase in asthma. Lancet. 1993;342:1510–1513
  20. Tarpey MM, Fridovich I. Review methods of detection of vascular reactive species nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite. Circ Res. 2001;89:224
  21. Frank TL, Adisesh A, Pickering AC, et al. Relationship between exhaled nitric oxide and childhood asthma. Am J Respir Crit Care Med. 1998;158:1032–1036
  22. Sergei A, Kharitonov SA, Yates DH, Barnes PJ. Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients. Am J Respir Crit Care Med. 1996;153:454–457
  23. Holgate S. Mediator and cytokine mechanisms in asthma. Thorax. 1993;48:103–109
  24. Steinberg HO, Chaker H, Learning R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. implications for the syndrome of insulin resistance. J Clin Invest. 1996;97:2601–2610
  25. Stefano GB. JAOA letters nitric oxide and anandamide in OMT research. J Am Osteopath Assoc. 2006;106:588–589
  26. Stefano GB, Stefano JM, Esch T. Anticipatory stress response: a significant commonality in stress, relaxation, pleasure and love responses. Med Sci Monit. 2008;14:RA17–21
  27. Benson H, Beary JF, Carol MP. The relaxation response. Psychiatry. 1974;37:37–45
  28. Wallace RK, Benson H, Wilson AF. A wakeful hypometabolic physiologic state. Am J Physiol. 1971;221:795–799
  29. Stefano GB, Goumon Y, Billifinger TV, et al. Basal nitric oxide limits immune, nervous and cardiovascular excitation: human endothelial express a mu opiate receptor. Prog Neurobiol. 2000;60:513–530
  30. Dusek JA, Chang BH, Zaki J, et al. Association between oxygen consumption and nitric oxide production during the relaxation response. Med Sci Monit. 2006;12:CR1–CR10

PII: S0161-4754(09)00301-7

doi: 10.1016/j.jmpt.2009.11.005

Journal of Manipulative and Physiological Therapeutics
Volume 33, Issue 1 , Pages 76-79 , January 2010